Yes, it’s important to stay hydrated when taking nitazoxanide, especially if you’re being treated for conditions like diarrhea or gastrointestinal infections, as these can lead to fluid loss. Drinking plenty of water helps maintain hydration, supports kidney function, and ensures the medication is effectively processed by your body. While nitazoxanide 500mg itself doesn’t directly require excessive water, proper hydration is vital during treatment for gastrointestinal issues. Always follow your doctor’s specific hydration recommendations, and consider oral rehydration solutions if diarrhea persists to replenish lost electrolytes as well.